The human brain is like a labyrinth of twisty little passages, all different. It’s like a big bowl of spaghetti, where every noodle represents a different thought or memory, and they’re all tangled up together. It’s a complex and mysterious organ, that’s for sure.
It’s like trying to understand a Rubik’s cube, but instead of colors, the different sides are emotions, memories, and thoughts. And just when you think you’ve got it all figured out, you turn one side, and everything falls apart.
It’s like trying to navigate through a maze, but instead of walls, it’s made of neurons, synapses, and electrical impulses. And let’s not forget about the different regions and functions of the brain. It’s like a city with different neighborhoods: the prefrontal cortex, the amygdala, the hippocampus. It’s like trying to find your way around a new city without a map.
Why do some people have more wrinkles on their brains than others
The intricate folds and wrinkles of the human brain are what gives it the ability to think, learn, reason and remember. And now, scientists have uncovered the reason why some people have more folds in their brains than others, in a condition known as polymicrogyria (PMG). PMG is caused by an abnormal thickening of the cortex, resulting in a host of problems such as developmental delays, intellectual disability, speech difficulties and seizures. The team of scientists found that PMG is caused by the tardy migration of brain cells during early development and identified a specific protein called transmembrane protein 161B (TMEM 161B) that is responsible for the condition. They found that the absence of this protein causes disrupted radial glial fibers and internal cytoskeleton, leading to an overfolded brain tissue. It’s like solving a puzzle that unveils the secrets of how our brain works and how it shapes our unique abilities.
Lu Wang, PhD, from the Gleeson lab and also the first author of the study, stated:
Once we identified TMEM161B as the cause, we set out to understand how excessive folding occurs,
We discovered the protein controls the cellular skeleton and polarity, and these control folding.
The new study appears in PNAS.