Ketamine is Able to Increase Brain Noise

Ketamine is Able to Increase Brain Noise

Ketamine is a powerful anesthetic that is often used in medical and veterinary settings, but it also has a reputation as a recreational drug. One amazing fact about ketamine is that it is sometimes used to treat depression and other mood disorders. In fact, ketamine has been shown to produce rapid and robust antidepressant effects in some people, which is pretty mind-blowing considering that it is most commonly associated with partying and getting high. So the next time you hear someone talk about “Special K,” just remember that this party drug might also have the power to lift your spirits in a more literal sense!

However, it is not a first-line treatment for depression and is not suitable for everyone. The use of ketamine for the treatment of depression is considered experimental, and it is not approved by the US Food and Drug Administration (FDA) for this use. It is typically only used as a last resort for people who have not responded to other treatments, such as antidepressants and therapy.

Ketamine can produce rapid and robust antidepressant effects in some people, but it can also have significant side effects, including hallucinations, confusion, and dissociation. It is also associated with the risk of abuse and addiction and is not recommended for long-term use.

Ketamine can inhibit NMDA receptors

According to a new study that reveals, ketamine works by inhibiting NMDA receptors, which results in an increase in noise at gamma frequencies in certain areas of the brain, including the thalamic nucleus and somatosensory cortex.
Some research suggests that this increase in background noise may impair the functioning of thalamocortical neurons, potentially leading to psychosis. This impairment may be related to an imbalance of inhibition and excitation in the brain, which may be caused by a malfunction in the case of NMDA receptors. Overall, these findings suggest that ketamine may have the potential to trigger psychosis by altering the balance of inhibition and excitation in the brain, potentially through its effects on NMDA receptors.

The new research belongs to an international team of researchers, and Sofya Kulikova, who is Senior Research Fellow at the HSE University-Perm, has also participated. 

Kulikova explained as quotes:

The discovered alterations in thalamic and cortical electrical activity associated with ketamine-induced sensory information processing disorders could serve as biomarkers for testing antipsychotic drugs or predicting the course of disease in patients with psychotic spectrum disorders.

This discovery may provide further insight into the underlying mechanisms of psychosis in schizophrenia, the mental disease affecting millions of people worldwide.

Schizophrenia: still a mysterious disease

Schizophrenia is a chronic mental disorder that can have an impact on how a person thinks, feels, and behaves. It is not fully understood what causes schizophrenia, but it is thought to be related to a combination of genetic, environmental, and brain development factors.

Research has shown that people with schizophrenia tend to have structural and functional abnormalities in certain areas of the brain, including the prefrontal cortex, amygdala, and hippocampus. These brain abnormalities may be present from birth or may develop over time and may be influenced by a variety of factors.

It is thought that genetic factors play a significant role in the development of schizophrenia, as people with a family history of the disorder are at higher risk of developing it. However, not everyone with a family history of schizophrenia will develop the disorder, and it is not inherited in a simple pattern. Environmental factors, such as exposure to toxins or infections during pregnancy or early life, may also increase the risk of developing schizophrenia.

The new findings were published in the European Journal of Neuroscience.

Cristian Antonescu

Even since he was a child, Cristian was staring curiously at the stars, wondering about the Universe and our place in it. Today he's seeing his dream come true by writing about the latest news in astronomy. Cristian is also glad to be covering health and other science topics, having significant experience in writing about such fields.

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