Heart Failure Has A Never-Before-Known Cause, Scientists Revealed

Heart Failure Has A Never-Before-Known Cause, Scientists Revealed
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According to an international team of scientists led by researchers from the University of Alberta, there is a hidden factor for heart failure, a never-before-known cause that might trigger circulatory disorders which might, at their turn, cause a dangerous condition that accounts for 20 percent of all cases of death due to heart failure.

The team of scientists spotted an essential molecule, dubbed as PI3K alpha, which binds to gelsolin, the enzyme can damage the filaments that help make up the structure of the heart’s cells. Eventually, PI3K alpha is surpassing those filaments that make the heart’s cells structure.

Gavin Oudit, a professor of cardiology at the University of Alberta, and director of the Heart Function Clinic at the Mazankowski Alberta Heart Institute stated that the recently found molecule, PI3K, is the key to a possible therapeutic target, promising for a better treatment for dilated cardiomyopathy than the current ones.

Heart Failure Has A Never-Before-Known Cause, Scientists Revealed

“You need some gelsolin, but when it gets out of control, it destroys things. The molecule chews up the filaments, and you get really bad heart failure. But we have also shown that when you suppress this molecule, you preserve your heart function. It’s intact,” explained Gavin Oudit from the University of Alberta.

“By understanding these patients better, we’ll hopefully be able to develop specific therapies for them,” he added. “But if we can now identify patients that have problems with this type of remodeling (dilated cardiomyopathy), we can target them specifically. That’s where we’re heading down the road. And to take this research right from the molecule to our patients, it’s very rewarding,” Oudit concluded.

“There are currently no specific treatments for patients with heart failure, as the same medications are used for all patients,” said Oudit, so, according to the expert, the new study is of great significance in helping scientists develop better therapies for preventing heart failure.


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