The composition of the intestinal microbiota, made up of billions of gut bacteria, is different in patients with obesity, HIV, HCV or multiple sclerosis, according to a recent Spanish meta-analysis conducted by Dr. Jose Antonio Oteo from the San Pedro University Hospital.
With the aim of analyzing the most recent studies published on gut bacteria, several Spanish researchers have come up with some news about microbiota and its connection with various diseases, such as heart failure and infectious diseases. The composition of the intestinal bacterial flora gives information about the microbiome. Recent studies have shown the relationship between the alterations of this set of bacteria and an increasing number of pathologies.
“In fact, we know that the composition of the microbiota is different in patients with obesity, HIV infection, HCV, multiple sclerosis and the hypothesis of acting on this microbiota to achieve the lost balance is very interesting. These infections alter the composition of the gut bacteria, leading to bacterial translocation and the setting in motion of inflammatory conditions that seem to be responsible for the increase in vascular risk presented by these patients”, said Dr. Oteo who also added that “there is still a lot of work to be done” in this regard.
Gut Bacteria Alterations Linked To Diabetes, HIV, Multiple Sclerosis, Cardiovascular Conditions, Among Others
The expert claims that the impact of commonly used drugs on the gut bacteria should be known. In addition to that, he considers that “an effort should be made to know the role played by prebiotics, probiotics and, why not, at a given moment, feces transplantation,” which is a practice that gains popularity.
“The potential of this study is that many other variables must be researched, so we will be able to investigate the role of the intestinal microbiota in a global context. In fact, the main novelties that are taking place in this sense are related to the methodology for the quantification of the microbiota, since the appearance of mass sequencing techniques has greatly facilitated its study but still has some limitations. Mainly the interpretation of the large amount of data generated, which makes its incorporation into clinical practice is slow,” explains Gome-Garre, also a researcher in the new meta-analysis, who added that patients with cardiovascular conditions have unbalanced gut bacteria.
Heart failure is only one of the diseases influenced by the alterations of the microbiota. Doctor Oteo pointed out that these alterations, “if not repaired by so-called resilience mechanisms, can lead to dysbiosis,” which in turn “has been associated with a growing number of pathological processes ranging from dental caries to cancer.”