According to recent research, memory loss in Alzheimer’s Disease might be restored thanks to new practices. However, the study focused on gene changes caused by influences other than DNA sequences, which made it possible for experts to address memory loss in animal models who have Alzheimer’s Disease.
“In this paper, we have not only identified the epigenetic factors that contribute to the memory loss, but we also found ways to temporarily reverse them in an animal model of Alzheimer’s Disease,” said Zhen Yan, the study’s leading author.
“We found that in Alzheimer’s disease, many subunits of glutamate receptors in the frontal cortex are downregulated, disrupting the excitatory signals, which impairs working memory,” continued Zhen Yan.
The scientists identified the loss of glutamate receptors is a consequence of an epigenetic process that the researchers call “repressive histone modification.” It is prevalent in the late stages of Alzheimer’s Disease.
Alzheimer’s Disease: Restoring Memory Loss Might Be Possible
“This AD-linked abnormal histone modification is what represses gene expression, diminishing glutamate receptors, which leads to loss of synaptic function and memory deficits,” explained Zhen Yan.
“Our study not only reveals the correlation between epigenetic changes and Alzheimer’s Disease, but we also found we can correct the cognitive dysfunction by targeting the epigenetic enzymes to restore glutamate receptors,” added Yan.
“On being given enzyme inhibitors, researchers saw the rescue of cognitive function that was confirmed through evaluations of recognition memory, spatial memory, and working memory. ‘At the same time, we saw the recovery of glutamate receptor expression and function in the frontal cortex,'” reported Business Standard, citing Zhen Yan.
Alzheimer’s Disease is the most prevalent form of dementia or cognitive impairment if you wish. While there’s no treatment whatsoever, the new study carried out by Zhen Yan might pave the way to new therapeutic approaches.