Alzheimer’s Disease Is Not Affecting The Cerebellum

Alzheimer’s Disease Is Not Affecting The Cerebellum
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Both accumulations of amyloid and tau proteins are the main characteristics of Alzheimer’s Disease, a condition that damages the neural cells over time, causing memory loss, among other issues. Scientist theorized that the illness is not the only one which causes changes in the brain, as the organ itself has to leave some marks, as it’s fighting the disease. However, in a recent study, the researchers noticed that Alzheimer’s Disease is not affecting the cerebellum.

The changes in the brain caused by itself when trying to fight the condition appeared as accumulations of different proteins, or the presence of new proteins. The scientists still hope that if they find which proteins are causing the damages in the brain in Alzheimer’s Disease patients, then new therapies might be produced.

A team of scientists from England and New Zealand compared the brains of patients who died from Alzheimer’s Disease with brain scans of people who died from cancer.

Alzheimer’s Disease Is Not Affecting The Cerebellum

The brains affected by Alzheimer’s Disease helped scientists come up with more than 24,000 different data points to reveal the changes that take place at the brain level in Alzheimer’s Disease patients.

According to the study, the hippocampus, entorhinal cortex, and cingulate gyrus are the most affected areas of the brain by Alzheimer’s Disease, while the motor cortex and sensory cortex showed less damage due to the condition. However, surprisingly, the cerebellum, which controls human movement and balance, didn’t seem affected by Alzheimer’s Disease.

“We also show that unaffected cerebellum, rather than being unaffected by AD, displays a pattern of protein expression changes distinct from other brain regions, which could be protective for this region of the brain,” the researcher noted in the study’s report. In short, cerebellum seems unaffected by Alzheimer’s Disease, at least, as far as it concerns the accumulation of proteins that characterize Alzheimer’s Disease.


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