Researchers from the University of Guelph in Canada have discovered a new antibody administration way which can prevent and even cure Ebola. Ebola is still a ‘mass murderer’ as it has killed over 11,000 people in West Africa during the last massive widespread of between 2013 and 2016.
Doctors realized back then that current medications used against Ebola are not effective and new ways of treatment are needed.
Recent studies could have found a new effective treatment – A new monoclonal antibody therapy (mAbs)
“Our goal is to make an antibody-based therapy that can protect against all strains of Ebola, and potentially Marburg virus, as well. It would be used to stop the spread of the virus in outbreak situations,” announced Sarah Wootton, a researcher at the University of Guelph, Canada.
The research on mAbs unveiled positive results and the scientists are optimistic that the recent discovery will cure Ebola.
Unfortunately, mAbs presents some downsides, namely, is very expensive to develop and is offering immunity for only a short period of time.
The newly developed process detours the requirement of a natural immune system response from the patients, therefore, fastening the immunization process.
The scientists discovered that adeno-associated virus (AAV) is able to produce antibodies that have been proven significantly efficient in holding the Ebola virus under control. However, the study has been conducted only on mice, at this moment, but researchers are believing it will show the same effectiveness in humans.
The method gave 100% protection in mice on which two variants of mAbs have been used
A combination of the two antibodies has been shown to offer protection against Ebola for almost 150 days but when the newly developed antibody gene was administered the protection lasted for more than 300 days.
“Developing pan-Ebola or pan-filovirus vaccines and therapeutics has been the goal (…) Our preliminary data is really encouraging and we will move forward to develop pan-Ebola/pan-filovirus cocktails,” admitted Xiangguo Qiu, a scientist at the Winnipeg’s National Microbiology Lab, Canada.