The Truth Behind High-Fats Diets According to Science

The Truth Behind High-Fats Diets According to Science

The latest studies warn us that diets high in fats may do more harm than good. How? It elevates the risks of heart attacks due to the damaging response that triggers in the heart. Beware the modern diets and the charm it exerts on us.

What Happens When Eating Fats?

The heart cells in mice were severely affected by high doses of fat due to the oxidative stress levels. The results appeared in a publication of Biochemical and Biophysical Research Communications.The mice have been fed 45% of their meals only fat, 20% protein, and 35% carbohydrate. The hearts of mice presented a fatal heart growth that produces twice the amount of oxidative stress. Cardiac hypertrophy, closely linked to heart diseases, lead the cells to grow 1.8 times in mice. Keep in mind that cutting fats from time to time lessens the chances to face the same issue at old age but balance is always the key.

Named first author Dr Sunbal Naureen Bhatti, from the University of Reading said:

“Our research shows one way in which a high-fat diet can cause damage to the muscle cells that make up our hearts. It appears that a switch happens at a cellular level when the mice were fed on a high-fat regime which causes a normally harmless protein, Nox2, to become overactive. The precise nature of how the Nox2 protein goes onto cause oxidative damage and set off destructive hypertrophy is still being researched.”

She also added: 

“We are really just scratching the surface of how the protein Nox2 responds to diets, but our research clearly demonstrates that high fat diets has the potential to cause significant damage to the heart.”

The Process of Heart Aging 

The key factors in the study were the protein Nox2 and ROS, a free radical that drives pathological damage in the organism. The protein Nox2 , believed to generate oxidative stress in the heart, was found in dangerous amounts among the mice that have been fed plenty of fats. The protein created a response with ROS (reactive oxygen species) that is responsible for a long list of pathologies, such as cancer, cardiovascular diseases, and premature aging.

Scientists wanted to make sure it’s the Nox2 that creates all the damage in the way. Consequently, they bred mice that were ‘immune to Nox2 as their cellular system could easily cease the activation of this specific protein. They were given a diet rich in fats which concluded in little to no oxidative stress. However, we are still vulnerable to this radical. 


Source: Study reveals high fat diets may over-activate destructive heart disease protein





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