Cilagicin is a word that you perhaps never heard about, but that will drastically change soon enough. It’s the moniker of an antibiotic that could make humans get rid of bacteria that are otherwise resistant to such drugs. Cilagicin has shown to be effective in mice, which automatically gives a lot of hope. The drug is able to combat infections such as MRSA.
Researchers from Rockefeller University managed to invent the new drug in question, according to SciTechDaily. The achievement was possible by using computational models of bacterial gene products.
Developing a new class of antibiotics might be possible via computer models
Scientists are now confident that the new findings might pave the way for developing a new class of antibiotics using computer models. That would surely be needed, as bacteria resistant to antibiotics spreading across the world might surely become a huge international threat one day.
A month ago, we spoke about a discovery of researchers from University College London (UCL) and Birkbeck, who led a team that found, for the first time, the structure that allows the transport of antibiotic-resistant genes between bacteria.
Sean F. Brady from Rockefeller University stated, as SciTechDaily quotes:
Bacteria are complicated, and just because we can sequence a gene doesn’t mean we know how the bacteria would turn it on to produce proteins,
There are thousands and thousands of uncharacterized gene clusters, and we have only ever figured out how to activate a fraction of them.
Professor Gabriel Waksman, the lead author of the study regarding the structure responsible for allowing the transport of genes between bacteria that are resistant to antibiotics, and who also serves as a Professor at the UCL Structural & Molecular Biology and Birkbeck, University of London, declared as Phys.org quotes:
We are in a global crisis of antibiotic resistance, which threatens to overcome healthcare systems all over the world—the World Health Organization describes antibiotic resistance ‘as one of the biggest threats to global health, food security and development today.
The new research about cilagicin was published in Science.