Researchers at Mount Sinai University have linked a potentially cancer-causing liver ailment in children to prenatal exposure to a wide range of endocrine-disrupting substances. The scientists at Mount Sinai University accomplished this breakthrough.
This study examines the association between prenatal exposure to certain chemicals and chemical combinations and the later onset of non-alcoholic fatty liver disease, and it is the first study of its type. The researchers employed cytokeratin-18 as a specific marker for the condition in children. Recent research published in JAMA Network Open emphasizes the need to better understand prenatal exposure to environmental chemicals as a risk factor for non-alcoholic fatty liver disease, which is on the rise in children and may lead to serious chronic liver disease and liver cancer in later life. The results appeared in the journal JAMA Network Open.
Our routine exposure to these compounds is inevitable given their widespread presence in the food supply, drinking water, and consumer products. In terms of public health, this is a big issue. These results show that exposure to many endocrine-disrupting substances throughout childhood increases the likelihood of developing non-alcoholic fatty liver disease in children. They also highlight the need for further study to better understand the role of environmental chemical exposures in the etiology of liver disease in combination with hereditary and lifestyle variables.
There has been a rise in the number of pediatric cases with non-alcoholic fatty liver disease in recent years. Six to ten percent of all youngsters and around a third of all overweight children suffer from this disease. Pesticides, plastics, flame retardants, hazardous metals, and other environmental toxins all fall under the umbrella term “endocrine-disrupting chemicals.”
One example is perfluoroalkyl substances (PFAS), sometimes called “forever chemicals.” Both nonstick cookware and food packaging make use of these chemicals. Polybrominated diphenyl ethers (PBDEs) are another kind of chemical utilized as a flame retardant in household goods and baby items. Each class of chemicals is put to good use.