Heart Failure Mortality Risk Increased By The Loss Of The Y Chromosome

Heart Failure Mortality Risk Increased By The Loss Of The Y Chromosome

According to recent findings, the natural process of aging may be responsible for the destruction of the Y chromosome, which results in an increased risk of cardiovascular collapse and also heart disease. In males, there is one X chromosome and one Y chromosome, whereas the majority of women have two X chromosomes. In addition, as men age, the Y chromosomes that are contained in their bodies tend to atrophy and vanish from the various cell types.

New evidence

After decades of examining the phenomena, experts didn’t find that males who have shed their Y chromosomes tended to have shorter lives until 2014. This discovery came after decades of conducting further research. There is growing evidence that Y chromosomes are linked to a variety of age-related disorders, including cancer, Alzheimer’s disease, and others. This loss, on the other hand, has remained unknown due to the fact that it is not known for certain if it is just a natural consequence of aging like wrinkles or gray hair.

An enormous database consisting of the genetic data of 500,000 individuals from the United Kingdom was analyzed by a team of specialists. More than forty percent of white blood cells in males with Y-chromosome loss were observed to have an enhanced risk of mortality from cardiovascular illness, coupled with a two- or threefold spike in the possibility of death from chronic cardiac failure or heart disease in contrast with men who had not lost their Y chromosomes. To put it differently, those who had the greatest amount of Y chromosomes removed from their genome also had the greatest likelihood of succumbing to heart disease in their later years.

Mice research

Although the Y chromosome is the smallest and contains few genes, its functions are not fully understood. It has been observed, however, that mosaic loss of the Y chromosome in blood cells frequently occurs with age, and this alteration is associated with various medical conditions. Sano et al. modeled this process in mice by reconstituting their bone marrow with cells lacking the Y chromosome 

The removal of Y chromosomes had no immediate effect on the younger mice, but it did cause them to deteriorate over time and cause them to pass away at an earlier age than mice that had their Y chromosomes intact. Fibrosis, a condition in which scar tissue develops in the heart, was more prevalent, as was a more rapid decrease in heart function as a consequence of the created myocardial failure. Both of these conditions were caused by the induced myocardial failure. A drug that reduces the risk of scarring in the heart proved successful in regaining a significant amount of the mice’s lost cardiac function. It was shown that a reduction in the number of Y chromosomes leads to the formation of scar tissue inside the lungs as well as the kidneys, and an increased frequency of cognitive impairment in older mice.



Anna Daniels

Anna is an avid blogger with an educational background in medicine and mental health. She is a generalist with many other interests including nutrition, women's health, astronomy and photography. In her free time from work and writing, Anna enjoys nature walks, reading, and listening to jazz and classical music.

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