It has been just revealed the fact that a new study has found the “presence of billions to hundreds of billions of DNA molecules per dose” in both Pfizer and Moderna mRNA injections. Check out more details below.
Covid vaccines in the news again
It has been just revealed the fact that Pfizer and Moderna covid vaccines contain something that conspiracy theorists have been saying for a really long time.
The process of producing nucleoside-modified RNA (modRNA) for SARS-CoV-2 vaccines involves in vitro transcription (IVT) reactions, where RNA polymerase transcribes from a DNA template, according to official notes. For the original Pfizer randomized clinical trial (RCT), the production of modRNA relied on a PCR-generated DNA template (Process 1).
To produce billions of doses, the DNA is cloned into a bacterial plasmid vector for amplification in Escherichia coli before linearization (Process 2).
— Disclose.tv (@disclosetv) October 19, 2023
However, this process introduces additional sequences not present in the Process 1 template, increasing the complexity of potential residual DNA. Moderna has used a similar plasmid-based process for both clinical trial and post-trial use vaccines.
Recent DNA sequencing studies have revealed significant levels of plasmid DNA in both Pfizer-BioNTech and Moderna modRNA vaccines.
These studies analyzed a limited number of lots, raising questions about the variance in residual DNA found internationally. It is, therefore, important to continue monitoring residual DNA levels to ensure the safety and efficacy of these vaccines.
The original notes that can be found in the study revealed the fact that “The preliminary evidence of a dose-response effect of residual DNA measured with qPCR and SAEs warrant confirmation and further investigation. Our findings extend existing concerns about vaccine safety and call into question the relevance of guidelines conceived before the introduction of efficient transfection using LNPs.”
More than that, it seems that “With several obvious limitations, we urge that our work is replicated under forensic conditions and that guidelines be revised to account for highly efficient DNA transfection and cumulative dosing.”