Colon cancer is a terrible disease that triggers nightmares in everyone’s minds. Now, experts seem to have discovered new genetic factors that can trigger the health issue. Check out the latest details below.
Colon cancer new risks addressed
Researchers at the Vanderbilt-Ingram Cancer Center in the United States have made significant progress in understanding the genetic aspects of colorectal cancer, a common and serious malignant tumor that has been extensively researched. This breakthrough may lead to better prevention and treatment options in the future.
Colorectal cancer, which encompasses both colon and rectal cancer, is a major health concern. It occurs when normal cells in the colon or rectum grow abnormally and form polyps that may become cancerous.
Early detection and treatment are crucial for effectively managing this condition. The World Health Organization reports that it is one of the most common types of cancer and is the second highest cause of cancer-related deaths worldwide.
Experts’ latest study
Researchers conducted a study using a genetic technique called transcriptomic-wide association study (TWAS) to explore connections between genetic components related to gene expression and those associated with a specific trait. They also employed splicing-TWAS to enhance their gene discovery efforts. According to Xingyi Guo, the senior author of the study, the team used new RNA-seq data with TWAS and splicing-TWAS to expand their gene search. PTI News reported on this study.
Recent research has revealed the role of two previously unknown genes, TRPSI and METRNL, in promoting colorectal cancer. The study also confirmed the cancer susceptibility of the recently reported gene, C14orfl66. This new information expands our understanding of the genetic factors that contribute to the development of colorectal cancer.
It is important to acknowledge the limitations of this research despite its significant advancement. The study mainly focused on individuals of European descent, and further research is necessary to determine the significance of these genes in non-European populations.
However, this study provides a hopeful direction for future research. Scientists aim to gain a better understanding of the biological mechanisms that cause colorectal cancer by combining population-based analyses with functional investigations. Ultimately, this knowledge could lead to more effective strategies for preventing and treating this disease.