Auvelity (Dextromethorphan and Bupropion) Can Overcome Major Depressive Disorder

Auvelity (Dextromethorphan and Bupropion) Can Overcome Major Depressive Disorder

Major Depressive Disorder (MDD) is one of the serious mental health conditions that can have significant impacts on individuals’ well-being and quality of life. While it is important to approach the topic with sensitivity, it is crucial to understand the potential dangers associated with MDD.

First of all, we need to discuss the condition’s impact on mental health. Major Depressive Disorder is characterized by persistent feelings of sadness, hopelessness, as well as a loss of interest in activities. The condition can lead to severe emotional distress, affecting a person’s overall mental well-being.
Impaired daily functioning is also an important subject when we talk about MDD. The disease can significantly impair an individual’s ability to carry out daily activities such as work, study, and social interactions.

Auvelity is indicated for the treatment of MDD in adults

Auvelity is a breakthrough treatment for adults with major depressive disorder (MDD) developed by Axsome Therapeutics, meaning a US-based biopharmaceutical company. This innovative therapy combines dextromethorphan and bupropion in a unique formulation, creating a multimodal N-methyl-D-aspartate (NMDA) receptor antagonist.

Auvelity (AXS-05) is available as extended-release oral tablets, specifically designed to provide long-lasting relief. Each tablet contains 45mg of dextromethorphan HBr and 105mg of bupropion HCl. These beige, round tablets are film-coated and feature a distinct 45/105 debossed imprint, packaged in a bottle containing 30 tablets.

Recognizing its potential, the US Food and Drug Administration (FDA) granted Auvelity the status of a breakthrough therapy for MDD treatment back in early 2019. This designation highlights the significant advancements and promising outcomes associated with this medication.
With the development of Auvelity, Axsome Therapeutics aims to provide a new avenue of hope for individuals battling MDD, offering a potential solution to alleviate symptoms and improve their quality of life.

How does Auvelity act?

Auvelity operates through a unique mechanism of action, harnessing the power of its key components to target various receptors and chemicals in the brain.

The dextromethorphan component serves as an uncompetitive NMDA receptor antagonist, which means that it’s capable of blocking the activity of NMDA receptors. This action allows it to modulate glutamatergic neurotransmission, a process crucial for the communication network of the brain. It also needs to be said that dextromethorphan acts as a sigma-1 receptor agonist, further influencing the brain’s signaling pathways.

The presence of bupropion in Auvelity enhances the bioavailability of dextromethorphan, ensuring its maximum effectiveness. Furthermore, bupropion acts as a norepinephrine and dopamine reuptake inhibitor. By inhibiting the reuptake of these neurotransmitters, bupropion helps to increase their availability in the patient’s brain, influencing mood regulation and overall brain function.

How does MDD manifest?

Depression, which is also known as major depressive disorder (MDD) or clinical depression, is a mood disorder that goes beyond temporary feelings of sadness. It brings about a persistent sense of profound sadness and a loss of interest in previously enjoyed activities. This condition can affect not only the patient’s mood but also his thoughts and behaviors, leading to various emotional and physical challenges. It can disrupt a person’s ability to carry out daily and usual tasks, making even ordinary activities seem overwhelming, and at times, he may question the value of life itself.

It’s important to keep in mind that depression is not a sign of weakness, and you cannot simply will yourself out of it. It is a complex condition that often requires long-term treatment. However, it’s crucial not to lose hope. With the right approach, most people with depression can experience significant improvement in their well-being.

Treatment for depression typically involves a combination of medication and psychotherapy. Medications can help alleviate symptoms and restore the balance of chemicals in the brain, while psychotherapy provides a supportive and therapeutic environment to explore and address the underlying causes of depression.

Nobody should ever underestimate the dangers of major depressive disorder. The lack of motivation, energy, and concentration associated with depression can have far-reaching consequences in multiple areas of life.


Even since he was a child, Cristian was staring curiously at the stars, wondering about the Universe and our place in it. Today he's seeing his dream come true by writing about the latest news in astronomy. Cristian is also glad to be covering health and other science topics, having significant experience in writing about such fields.

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