As of this day, a male contraceptive pill is one step closer to becoming a reality after decades of hard work. To put it another way, scientists claim to have produced a pill that is 99 percent effective in preventing pregnancy. YCT529, a non-hormonal medication tested on mice, had no obvious negative effects.
According to the researchers, the rats were able to reproduce after four to six weeks of discontinuing the contraception. The medicine, which blocks a protein that prevents the creation of sperm, will be tested on humans later this year by scientists at the University of Minnesota. Other options exist, some of which have recently been tested on males in the United Kingdom. Gunda Georg, the study’s leader, claims that YCT529 is “far and beyond” all other contraceptives for males.
A four-week course of oral administration of the medicine ‘dramatically lowered’ the sperm count in mice, according to the scientists. It also functioned without any obvious negative effects and was 99 percent successful in avoiding pregnancy.
Male oral contraceptives, including tablets, gels, and injections, have been the subject of scientific research since the 1950s. Even the most promising alternatives are still some years away from widespread availability.
Most of the medications being tested in clinical trials target testosterone, preventing the male sex hormone from promoting healthy sperm cell production. There are concerns, however, about weight gain, depression, and a rise in cholesterol as a result of testosterone-blocking.
While the female combination contraceptive pill has been related to comparable mental health adverse effects, it includes synthetic copies of the female hormones estrogen & progesterone. Minor risks of blood clots as well as breast cancer have been linked to the pill, besides an increased blood pressure, according to the National Institutes of Health.