In worms, flies, and rats, including monkeys, researchers have shown that limiting overall caloric consumption while supplying all needed nutrients may increase longevity.
Physiological characteristics that enhance the lifespan and postpone age-related illness are seen in all of these creatures, according to the study.
Calorie restriction in humans, which involves decreasing the mean calorie consumption by around a 1/3, may also prolong the human lifetime, however, concrete proof is presently missing in this regard.
The circadian clock, which regulates daily rhythms of biology, metabolism, and activities like feeding, has been shown in animal experiments to have an influence on the timing of energy restriction. In addition to aging, this was also related.
Calorie limitation extends the longevity of mice in several experiments. However, the majority of this study has included scientists feeding experimental mice calorie-restricted regimens throughout the day.
As nocturnal creatures, mice have adapted to eat throughout the night.
As a result, the researchers installed automated feeders to guarantee that a few of the rodents were only fed at night for the sake of their research. The longest lives were found in mice whose caloric intake was confined to only 12 hours a day throughout their active period, with the rest of the time spent fasting. Animals in this study lived an average of 35% longer than their control counterparts.
A calorie-limited regimen also enhanced the rodents’ ability to regulate their blood sugar levels & insulin tolerance, but the effects were strongest in mice who only ate at night, researchers discovered.
Aging raised the expression of genes mediators of inflammation while decreasing the expression of genes related to metabolism including body clock, in all of the mice studied, according to the scientists.
These age-related alterations were decelerated by calorie counting, although the greatest effect was shown in rats that only ate one meal a day.
The findings were reported in Science.