The search for eternal life and longevity has been a topic deeply researched throughout human history.
In ancient times, people embarked on adventures looking for the holy grail and the fountain of youth, while doctors and healers researched plants and medicines to achieve said results.
Although legends and myths were never proven to be more than that, modern science has discovered multiple authentic ways to achieve a healthy life and prolong a person’s lifespan.
One of the most outstanding discoveries that have contributed to enhanced longevity was the supplementation using NMN, a molecule found naturally in the human body and different types of food, such as fruits and vegetables.
We will explain in this article what NMN is, how it can contribute to our longevity and the science behind it.
What is NMN?
NMN is a molecule that can be vastly found in the human body. The acronym NMN stands for Nicotinamide Mononucleotide.
Furthermore, it is also the most abundant molecule in the body after water, playing a vital role in longevity as it can reduce aging symptoms.
It was first observed in 1906. Since then, it has been studied for its effect on metabolism and its relationship with aging and longevity.
It resides inside the cell’s nucleus, cytoplasm, and mitochondria. Nonetheless, it also drifts freely on the different body fluids, such as urine and blood. Lastly, it can be found on placenta tissues during pregnancy.
NMN molecule was placed on supplements for human consumption after diverse research and studies proved its beneficial anti-aging properties without any adverse side effects.
Biochemically, this molecule acts as a precursor to the coenzyme NAD+ (Nicotinamide Adenine Dinucleotide), meaning that NAD+ is created from an NMN molecule.
Furthermore, this coenzyme plays a vital role in cellular aging and overall health. Therefore, consuming NMN helps produce and maintain optimal levels of NAD+, which results in increased longevity.
How does NAD+ affect longevity?
The coenzyme NAD+ is used by different cells in the body for a series of enzymatic reactions, actively participating in biological processes such as DNA repair, aging, cell death, and more.
Furthermore, increased levels of NAD+ are responsible for enhancing survival by improving cellular repair and boosting energy production.
NAD+ levels on the organism are higher during childhood and early years as the body is still changing and maturing. However, the amount of NAD+ starts decreasing once full maturity has been achieved around middle age.
The reason behind it is an increased activity of the enzyme CD38, which degrades and eliminates NAD+ and lowers its concentration. The number of this coenzyme present in the body can drop as low as half of what it used to be, triggering metabolic reactions that lead to the common signs of aging.
These signs include:
- Mitochondrial dysfunction
- Cessation of cellular division
- DNA instability and damage
- Epigenetic shifts
However, increasing the NAD+ levels once they start to fall has been proven to be effective to reduce the signs of aging and increase longevity.
Moreover, supplying the body with NMN has been proved to be effective in increasing NAD+ levels. This not only increases longevity, but also improves different age conditions related to aging, such as increasing insulin sensitivity.
How does NMN work?
NMN travels through the body to the cells, where it will transform into NAD+. However, this process requires the NMN to undergo a few transformations before turning them into the desired coenzyme.
To get inside the cell, NMN has to either transform into a new molecule called NR to penetrate the cell walls and then transform into NMN again once inside or get help from a specialized enzyme that allows it to enter the cell without altering its structure.
Once the NMN is inside the cell, it is ready to turn into NAD+ through 3 different pathways. However, the most common and efficient one is the salvage pathway.
This process consists of merging NMN with ATP, a molecule used as energy to perform different cellular interactions, using the help of an enzyme called NAMPT. The result of this combination is a new NAD+ that will be ready to apply its anti-aging effect.
Different studies performed in mice revealed that NMN not only prolongs life span but also improves the condition of many age-related diseases and conditions.
Among the positive results obtained, some stood out above the others, such as:
- Enhanced physical activity and metabolism
- Improved insulin sensitivity
- Prevention of gene changes associated with DNA damage due to age
- Improved action and secretion of insulin on subjects with type 2 diabetes
- Prevention of heart attacks
- Restoration of aged skeletal muscle
- Reduced advance of Alzheimer
Researchers found out during the studies that NMN is stable in the water, meaning it can be suspended in it at room temperature for around 7 – 10 days without being degraded or suffering any structural changes.
Furthermore, it was also observed that it takes NMN only 2 minutes to enter inside the cells after being consumed via oral ingestion.
NMN supplements for a long life
Although NMN can be obtained by eating different types of food such as tomatoes, cabbages, shrimps, raw beef, and mushrooms, the amount provided by them is not enough to maintain high levels of NAD+ once it starts to decrease.
Therefore, consuming NMN via supplementation is the best alternative to prolong life and gain the natural anti-aging effect it provides.
NMN can be acquired at physical supplement stores and online on sites, such as Hello100.com, where it is possible to place an order in just a couple of minutes.
The bottom line
NMN is a molecule found inside the body that plays a vital role in the synthesis of NAD+, a coenzyme that participates in the metabolic processes that lead to aging.
Finally, although NAD+ levels decrease upon reaching middle age and trigger a series of symptoms associated with aging, consuming NMN via supplements can maintain NAD+ at optimal concentrations and have a positive impact on longevity. As a result, it can prolong lifespan and reduce the risk of suffering from age-related diseases or prevent them from developing early on, allowing people to enhance their health.